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Title   전이성 위암에 대한 Cispatin(p) , Etoposide(E) , 5-Fluorouracil(F) : PEF 복합화학요법의 제 2 상 임상시험 ( A Phase 2 Trial of PEF ( Cispatin , Etoposide , 5-Fluorouracil ) Chemotherapy for Metastatic Stomach Cancer )
Publicationinfo   1998 Jan; 030(05): 900-907.
Key_word   Stomach cancer, Cisplatin, Etoposide, 5-tluorouracil, Chemotherapy
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Abstract   Purpose: To determine the activity and toxicities of PEF (Cisplatin, Etoposide, 5-Fluorouracil) chemotherapy for stomach cancer. Materials and Methods: Patients with previously untreated metastatic stomach cancer were treated with PEF regimen which consisted of cisplatin (20 mg/§³ i.v. days 1~5), etoposide (100 mg/§³ i.v. days 1, 3, 5), and 5-fluorouracil (5-FU)(800 mg/§³ i.v. infusion for 12 hours days 1~5). Chemotherapy was repeated every 3 weeks until disease progressed or toxicities were intolerable. Results: Between May 1989 and July 1990, 40 patients were enrolled in this protocol. Twelve patients were lost to follow up after one cycle of chemotherapy and inevaluable. After 2~8 cycles (median 3) of chemotherapy, 20 out of 28 evaluable patients showed objective responses without any complete response, making the response rate 71% (95% confidence interval: 54~89%). The responses lasted from 4+ to 39 weeks (median: 38 weeks). The overall survival of total evaluable patients was 4+ ~50+ weeks (median 38 weeks). Among total 109 cycles of chemotherapy, cycles were delayed or doses were reduced in 48 cycles (44%) because of leukopenia (in 61 cycles: 56%) and/or thrombocytopenia (in 14 cycles: 13%). However, there was no treatment-related death. Nausea/vomiting and alopecia were experienced in most of patients. The stomatitis was experienced in 7 patients (25%) but completely reversible. In contrast, the peripheral neuropathy which developed in 4 patients (14%) after 5 cycles of chemotherapy was not reversible. Conclusion: The PEF regimen was active and tolerable in stomach cancer.
저 자   강윤구(Keun Chil Park),염광섭(Kwang Seob Yum),조희준(Hee Jun Cho),이진오(Jhin Oh Lee),강태웅(Taik Koo Yun)